Development of cosmeceutical formulations based on mushroom extracts and compounds

Time: 4:10 pm - 4:30 pm

Date: 23/10/2019

Theatre: Room 3

23-10-2019 16:10 23-10-2019 16:30 Europe/London Development of cosmeceutical formulations based on mushroom extracts and compounds

Cosmeceuticals are described as products in the forms of creams, ointments or lotions with biologically active ingredients, topically applied to improve the physical appearance and overall health of the skin. There is constant search for novel and improved natural ingredients to serve as suitable cosmeceutical raw-materials, and mushrooms represent an underexploited source. Therefore, the cosmeceutical… Leer más »

Cosmetorium

Synopsis

Cosmeceuticals are described as products in the forms of creams, ointments or lotions with biologically active ingredients, topically applied to improve the physical appearance and overall health of the skin. There is constant search for novel and improved natural ingredients to serve as suitable cosmeceutical raw-materials, and mushrooms represent an underexploited source. Therefore, the cosmeceutical potential of some mushroom species was evaluated in terms of anti-inflammatory, anti-tyrosinase, antioxidant, and antimicrobial properties. This was followed by detailed characterization of the bioactive extracts in terms of phenolic acids, triterpenes and ergosterol composition. The extracts were incorporated into base cosmetic creams, and in vitro safety evaluation of the extracts and developed formulations was carried out using MTT and LDH assays in keratinocyte (HaCaT) and fibroblast (HFF-1) cell lines. Topical bioavailability of the compounds in the extract was evaluated using a Franz diffusion apparatus with pig ear skin as permeation membrane. The extracts had strong antioxidant, anti-inflammatory and tyrosinase inhibitory activities, while also displaying microbial inhibition against most commonly found contaminants posing microbial spoilage in cosmetics. Important bioactive compounds in the extracts include ganoderic acid C2, ganoderenic acid D, protocatechuic, p-hydroxybenzoic and syringic acids. The absence of toxicity to skin cell lines is indicative of the safety of these extracts for cosmeceutical purposes. The results observed in this study provide evidence for the utilisation of mushrooms as promising cosmeceutical ingredients.

Acknowledgements: FCT and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2019); FEDER-Interreg España-Portugal programme for financial support through the project 0377_Iberphenol_6_E; European Agricultural Fund for Rural Development (EAFRD), through the Rural Development Program (PDR2020), within the scope of Project MicoCoating (PDR2020-101-031472).

Speakers

  • View full profile for Isabel C.F.R. FerreiraIsabel C.F.R. Ferreira Director of the Mountain Research Centre and Pro-President of the Polytechnic Institute of Bragança, Portugal

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