Innovatorium 008: Stand 557

Vytrus Biotech

Toleroxyl™: reeducando la piel urbana

 

Toleroxyl™ is the first cosmetic active designed to generate tolerance. It reprograms the skin’s immune response by activating the GM-CSF receptor on Langerhans cells, offering a pioneering immune-reeducation approach to skin hyperreactivity. Unlike conventional soothing actives, it doesn’t suppress the alarm signal: it trains skin to stop reading harmless urban stimuli as threats, through its proprietary mechanism, the Tolerogenic Reset.

Designed from a human protein and grown in a plant biofactory, its goal is to stimulate Langerhans cells to increase skin tolerance. Toleroxyl™ binds to GM-CSF receptors, activating the NF-kβ pathway (key to controlling immune responses) to keep these cells in a calm state, reducing CD80/86 and CCR7, and increasing TGF-β secretion, which helps reduce inflammatory signals (TNF-α, IL-8, and IL-6).

Clinically, Toleroxyl™ has shown a reduction in redness of down to 65.3%, an improvement in erythema in more than 90% of cases at day 28, and a 100% improvement in the functional signs of hyperreactive skin (burning, itching, stinging, tightness), along with reinforcement of the skin barrier.

Phyto-PDRN and ExoPDRN ™

 

Vytrus Biotech introduces an exclusive plant-based PDRN innovation that redefines skin regeneration through advanced biotechnology.

Derived from low molecular weight DNA fragments obtained directly from plant cell cultures, this PDRN preserves its natural, intact structure and full biological potential.

The technology combines Phyto-PDRN and ExoPDRN™, enabling a dual-action approach that works both at the cellular surface and within the cell. By activating regenerative pathways such as the “salvage pathway,” it enhances cell survival, stimulates collagen synthesis, and supports tissue repair.

This breakthrough represents a new generation of high-performance, ethical cosmetics—offering a smart, sustainable strategy for skin rejuvenation using 100% plant-origin biotechnology.