Circanblue™ – Provital

The increasing digitisation exacerbated people’s desire to disconnect and reconnect with their natural wellbeing. The circadian cycle is a critical factor in maintaining this wellbeing.
Now that recent studies showed how peripheral circadian clocks in the skin play a vital role in regulating its physiological metabolism, Provital developed Circanblue™, a 100% natural cosmetic ingredient that resynchronises the skin’s circadian rhythm after digital overexposure.
This active is a vegan postbiotic, as it is biotechnologically obtained from the probiotic Lactococcus lactis. Its ability to induce an epidermal circadian resynchronization was quantified by the circadian expression rhythms of CLOCK and CRY1 after perturbations with blue light. Furthermore, its action against skin aging was demonstrated by the significant upregulation of the expression of a melatonin receptor, a skin-repairing enzyme (SIRT1), and two key detoxifying enzymes (NQO-1 and HMOX1), thus proving both its chrono-protective and well-aging effects.